Recommended initial HIV antiretroviral regimens for most patients¹

INSTI plus 2 NRTIs

• Bictegravir/tenofovir alafenamide/emtricitabine (Biktarvy)
• Dolutegravir (Tivicay) plus:
  • Emtricitabine/tenofovir alafenamide (Descovy)
  • Emtricitabine/tenofovir disoproxil fumarate (Truvada)

INSTI plus 1 NRTI²

• Dolutegravir/lamivudine (Dovato)

1. A forward slash (/) indicates that the components are available in a combination pill.
2. Do not use if pretreatment HIV RNA > 500,000 copies/mL, there is known hepatitis B coinfection, or HIV genotyping is not available.

INSTI = integrase strand transfer inhibitor; NRTI = nucleoside reverse transcriptase inhibitor.