Clinical features of eosinophilic granulomatosis with polyangiitis

Prodromal phase
(2nd & 3rd decades
of life)

Atopic disease

• Asthma
• Allergic rhinitis
• Chronic rhinosinusitis with nasal polyps

Eosinophilic phase
(>10% peripheral
blood eosinophilia)

Eosinophilic infiltration of multiple organs

• Lungs: migratory pulmonary opacities

• GI: eosinophilic enteritis (bleeding, obstruction, perforation)

Vasculitic phase
(3rd & 4th decades
of life)

Organ-threatening systemic vasculitis

• Nervous system: mononeuritis multiplex (peripheral nerve ischemia)
• Cardiovascular: myocarditis & conduction defects (leading cause of mortality)
• Kidneys: necrotizing glomerulonephritis (usually pANCA)
• Skin: tender subcutaneous nodules (granulomas)
• Musculoskeletal: migratory polyarthritis

pANCA = positive antineutrophil cytoplasmic antibody.