Clinical features of Alzheimer disease

Early
findings

• Anterograde memory loss (ie, immediate recall affected, distant memories preserved)
• Visuospatial deficits (eg, lost in own neighborhood)
• Language difficulties (eg, difficulty finding words)
• Cognitive impairment with progressive decline

Late
findings

• Neuropsychiatric (eg, hallucinations, wandering)
• Dyspraxia (eg, difficulty performing learned motor tasks)
• Lack of insight regarding deficits
• Noncognitive neurologic deficits (eg, pyramidal & extrapyramidal motor, myoclonus, seizures)
• Urinary incontinence