Indications for statin therapy in the prevention of ASCVD

Secondary prevention

Established ASCVD

  • Acute coronary syndrome
  • Stable angina
  • Arterial revascularization (eg, CABG)
  • Stroke, TIA, PAD
  • Age ≤75: High-intensity statin
  • Age >75: Moderate-intensity statin

Primary prevention

LDL ≥190 mg/dL
  • High-intensity statin

Age ≥40 with diabetes mellitus
  • 10-year ASCVD risk ≥20%:
    High-intensity statin
  • 10-year ASCVD risk <20%: Moderate-intensity statin

Estimated 10-year ASCVD
risk >7.5%-10%

(Pooled Cohort Equations)
  • Moderate- to high-intensity statin*
*High-intensity statins include atorvastatin 40-80 mg & rosuvastatin 20-40 mg; moderate-intensity statins include atorvastatin 10-20 mg, rosuvastatin 5-10 mg, simvastatin 20-40 mg, pravastatin 40-80 mg & lovastatin 40 mg.

ASCVD = atherosclerotic cardiovascular disease; CABG = coronary artery bypass grafting; PAD = peripheral artery disease; TIA = transient ischemic attack.