Occupational HIV postexposure prophylaxis

High-risk contact

(prophylaxis recommended)

Exposure of:

• Mucous membrane, nonintact skin, or percutaneous exposure

Exposure to:

• Blood, semen, vaginal secretions, or any body fluid with visible blood (uncertain risk: cerebrospinal fluid, pleural/pericardial fluid, synovial fluid, peritoneal fluid, amniotic fluid)

Low-risk contact

(prophylaxis not recommended)

Exposure to:

• Urine, feces, nasal secretions, saliva, sweat, tears (with no visible blood)

Timing

• Initiate urgently, preferably in the first few hours
• Continue for 4 weeks

Regimen

Treatment with ≥3-drug regimen recommended:

• Two nucleotide/nucleoside reverse transcriptase inhibitors (eg, tenofovir, emtricitabine)

PLUS:

• Integrase strand transfer inhibitor (eg, raltegravir), protease inhibitor, or nonnucleoside reverse transcriptase inhibitor