Alzheimer disease risk factors

Modifiable risk factors

Genetic risk factors

• Cerebrovascular disease
• Obesity
• Type 2 diabetes mellitus
• Hypertension
• Dyslipidemia & atherosclerosis
• Physical inactivity
• Brain trauma

• Early-onset familial AD
  • PSEN1
  • PSEN2
  • APP
• Late-onset AD
  • APOE

AD = Alzheimer disease; APOE = apolipoprotein E; APP = amyloid precursor protein; PSEN = presenilin gene.