Among other questions I crossed over this one:
A healthy women delivers a female newborn at term with a cranial malformation.
Physical examination of the newborn shows a large defect in the calvaria, and the meninges with the primitive brain. The newborn dyes 2 days later.
In this patients future pregnancies, and increase maternal serum concentration of which of the following during the second trimester will most likely indicate the same malformation?
1. alfa-fetoprotein
2.Beta HcG
3.inhibin A
4. pregnancy associated plasma protein A
5. Unconjugated estriol.

Apparently correct answer is alfa-fetoprotein.
Assuming that is was Patau syndrome ( defect in calvaria, primitive brain, holoprosencefaly is primitive brain, still nor divided into two hemispheres) as per FA all parameters in Patau syndrome are normal during pregnancy: normal alfa-feto, normal beta HcG, normal estriol, normal inhibin A.
Or, that was not Patau???
I would really appreciate some others opinion about this!!
THank you,
Dusha