cause of hypercalcemia in Multiple myeloma
does anyone know what causes hypercalcemia in MM?Is it TNF and IL-1?
In myeloma patients, the primary cause of the hypercalcemia is widespread tumor-induced bone destruction. This is primarily due to increased osteoclastic bone resorption caused by potent cytokines expressed or secreted locally by the myeloma cells (receptor activator of nuclear factor-κB ligand [RANKL], macrophage inflammatory protein [MIP]-1α, and tumor necrosis factors [TNFs].
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